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8.2. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated NR3C1 gene

SG Caradonna , NR Einhorn , V Saudagar , H Khalil , GH Petty , A Lihagen , C LeFloch , FS Lee , H Akil , A Guidotti , BS McEwen , E Gatta , J Marrocco

Transl Psychiatry. 2022; 12(1): 109. PMID: 35296634 https://pubmed.ncbi.nlm.nih.gov/35296634/Brief Summary: This mouse study identified sex and genotype-dependent effects of oral corticosterone on behavioral and physiological outcomes as well as on gene expression and epigenetics in hippocampal subregions.Glucocorticoids exert their effects by binding to glucocorticoid...

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ey0018.6-13 | Basic Research in Gender Dysphoria | ESPEYB18

6.13. Behavioral and neurobiological effects of GnRH agonist treatment in mice - potential implications for puberty suppression in transgender individuals

C Anacker , E Sydnor , BK Chen , CC LaGamma , JC McGowan , A Mastrodonato , HC Hunsberger , R Shores , RS Dixon , BS McEwen , W Byne , HFL Meyer-Bahlburg , W Bockting , AA Ehrhardt , CA Denny

Neuropsychopharmacology. 2021 Apr;46(5):882890.doi: 10.1038/s41386-020-00826-1. PMID: 32919399.This mouse study addresses the question of the psychological effects of treatment with the GnRH analogue (GnRHa) leuprolide. Six-week-old, i.e. early-pubertal, male and female mice were injected daily with leuprolide (20 μg) or saline for 6 weeks. The mice were subjected to a number...

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ESPE Yearbook of Paediatric Endocrinology

8.2. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated NR3C1 gene

6.13. Behavioral and neurobiological effects of GnRH agonist treatment in mice - potential implications for puberty suppression in transgender individuals

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